AI Article Synopsis
- Aging leads to complex changes in the immune system, referred to as "immunosenescence," characterized by weaker responses to infections and higher levels of inflammation.
- "Inflammaging," a low-grade chronic inflammation typical in older adults, contributes to increased risks for various age-related diseases.
- The article examines changes in both innate and adaptive immunity in the elderly, focusing on the rise of autoimmune conditions and the prevalence of autoantibodies in this age group.
Article Abstract
Aging is a very complex process, resulting in dysregulation of multiple systems. The most prominent changes in immunological function, termed «immunosenescence», are diminished immune response against infection, increased levels of pro-inflammatory mediators and increased risk of autoimmunity. Immunoscenescence is accompanied by the low-grade aseptic inflammation observed commonly in elderly people - «inflammaging», which is associated with a higher incidence of chronic non-infectious age-associated diseases. The article discusses the main changes in innate and adaptive immunity in aging and their impact on the induction of autoimmune processes, provides data on the frequency of autoantibody detection in the elderly and the clinical features of some autoimmune diseases debuting at this age.
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