AI Article Synopsis
- The Type VI secretion system (T6SS) is a tool used by Gram-negative bacteria to transport proteins into other cells, including both bacterial and eukaryotic targets.
- These transported proteins, known as effectors, perform various functions that enhance the survival and competitiveness of the bacteria that secrete them.
- The text explores different delivery methods of T6SS effectors and their mechanisms of action, revealing that their roles extend beyond merely harming adjacent cells.
Article Abstract
The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread among Gram-negative bacteria and used as a means to deliver effectors directly into target bacterial or eukaryotic cells. These effectors have a wide variety of functions within target cells that ultimately help the secreting cell gain a competitive fitness advantage. Here, we discuss the different ways in which these effectors can be delivered by the T6SS and the diverse mechanisms by which they exert their noxious action upon recipient cells. We also highlight the existence of roles for T6SS effectors beyond simply the killing of neighbouring cells.
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| http://dx.doi.org/10.1111/cmi.13241 | DOI Listing |
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