Oligonucleotide probes specific for detection of the TEM-1 and OXA-1 beta-lactamase genes were compared with isoelectric focusing in 114 gram-negative beta-lactamase-producing strains representing at least 16 species. Correlations of 96 and 100% with isoelectric points were found for the TEM-1 and OXA-1 probes, respectively.
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http://dx.doi.org/10.1128/AAC.32.3.397 | DOI Listing |
Int J Antimicrob Agents
December 2024
Texas Tech University School of Veterinary Medicine, Amarillo, TX 79106, United States. Electronic address:
Background: The study aimed to review the beta-lactamase resistance genes detected in Enterobacterales from humans, animals, and the environment in the United States.
Methods: We conducted a comprehensive search on PubMed, Web of Science, and Google Scholar for articles reporting beta-lactamase genes in the United States from 1981 to 22 April 2022, following the PRISMA protocol. Studies were evaluated based on predefined eligibility criteria, and both qualitative and quantitative analyses were conducted on the selected studies.
Microbiol Spectr
November 2024
Research Service, Veterans Affairs Northeast Ohio Healthcare System, Cleveland, Ohio, USA.
Taniborbactam (formerly VNRX-5133) is a novel, investigational boronic acid β-lactamase inhibitor. The combination of cefepime (FEP) with taniborbactam is active against carrying class A, B, C, and/or D enzymes. We assessed the activity of FEP-taniborbactam against clinical strains carrying ( = 50, 100%), of which 78% harbored at least one extended-spectrum β-lactamase (ESBL).
View Article and Find Full Text PDFJ Glob Antimicrob Resist
December 2024
Department of Contaminants and Biohazards, Institute of Marine Research (IMR), Bergen, Norway. Electronic address:
Objective: The aim of the current study was to determine the genomic map of the resistance genes of two CTX-M-15-carrying Escherichia coli strains belonging to novel sequence type (ST) 11873. Complete, closed genome sequences of the E. coli strains were obtained by applying a combination of short-read Illumina and long-read Oxford Nanopore-based sequencing.
View Article and Find Full Text PDFAntibiotics (Basel)
May 2024
Department of Food Microbiology, Hygiene and Safety, Institute of Food Science and Technology, Hungarian University of Agriculture and Life Sciences, Somlói út 14-16, H-1118 Budapest, Hungary.
The spread of superbugs in dairy products can jeopardize global public health. To date, information on the incidence rates of virulent and β-lactams-resistant (BLR) in cheeses from rural areas of Egypt has been lacking. Biochemical, serological, antibiotic susceptibility, and multiplex PCR (M-PCR) tests were performed to identify and characterize isolates.
View Article and Find Full Text PDFEcotoxicol Environ Saf
June 2024
College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, PR China. Electronic address:
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