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Maternal factors regulating preimplantation development in mice. | LitMetric

Maternal factors regulating preimplantation development in mice.

Curr Top Dev Biol

Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD, United States. Electronic address:

Published: August 2021

AI Article Synopsis

Article Abstract

Mammalian embryogenesis depends on maternal factors accumulated in eggs prior to fertilization and on placental transfers later in gestation. In this review, we focus on initial events when the organism has insufficient newly synthesized embryonic factors to sustain development. These maternal factors regulate preimplantation embryogenesis both uniquely in pronuclear formation, genome reprogramming and cell fate determination and more universally in regulating cell division, transcription and RNA metabolism. Depletion, disruption or inappropriate persistence of maternal factors can result in developmental defects in early embryos. To better understand the origins of these maternal effects, we include oocyte maturation processes that are responsible for their production. We focus on recent publications and reference comprehensive reviews that include earlier scientific literature of early mouse development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8394711PMC
http://dx.doi.org/10.1016/bs.ctdb.2019.10.006DOI Listing

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