AI Article Synopsis
- - Gao et al. found that older women have reduced fat breakdown (lipolysis) due to increased activity of the catecholamine-degradation pathway in their subcutaneous fat cells.
- - Unlike what is seen in mice, where these pathways are prominent in immune cells, in women they are primarily enriched in adipocytes (fat cells).
- - This indicates that the mechanisms of aging related to fat metabolism may differ between species.
Article Abstract
Gao et al. report that the observed reduction in adipose lipolysis with age in women could be explained by an upregulation of the catecholamine-degradation pathway in subcutaneous adipocytes. However, in contrast to findings in mice, these pathways are enriched in adipocytes and not in immune cells, suggesting species-specific differences in aging mechanisms.
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| http://dx.doi.org/10.1016/j.cmet.2020.06.007 | DOI Listing |
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