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A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells. | LitMetric

A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells.

Chem Commun (Camb)

Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China. and Key Laboratory of Biochip Technology, Biotech and Health Centre, Shenzhen Research Institute of City University of Hong Kong, Shenzhen, 518057, P. R. China.

Published: July 2020

AI Article Synopsis

  • A new fluorescent sensor called MRMP-1 was developed that can quickly and stably attach to plasma membranes.
  • This sensor shows significant fluorescence enhancement, allowing for real-time monitoring of changes in cell membranes under various stimuli.
  • MRMP-1 is the first of its kind to successfully label exosomes in living cells, paving the way for further studies in cellular dynamics.

Article Abstract

A rotor-based probe MRMP-1 was designed and synthesized. MRMP-1 can bind to plasma membranes very quickly and stably with remarkable fluorescence enhancement. It can be used to monitor the dynamic changes in cell membranes in real-time under stimuli conditions. Importantly, MRMP-1 is the first rotor-based fluorescent sensor to label exosomes in living cells.

Download full-text PDF

Source
http://dx.doi.org/10.1039/d0cc03069dDOI Listing

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