Rapidly scalable mechanical ventilator for the COVID-19 pandemic.

Intensive Care Med

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Published: August 2020

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314912PMC
http://dx.doi.org/10.1007/s00134-020-06113-3DOI Listing

Publication Analysis

Top Keywords

rapidly scalable
4
scalable mechanical
4
mechanical ventilator
4
ventilator covid-19
4
covid-19 pandemic
4
rapidly
1
mechanical
1
ventilator
1
covid-19
1
pandemic
1

Similar Publications

Iris: A Next Generation Digital Pathology Rendering Engine.

J Pathol Inform

January 2025

University of Michigan Medical School, Department of Pathology, 2800 Plymouth Road, Ann Arbor, MI 48109-2800, USA.

Digital pathology is a tool of rapidly evolving importance within the discipline of pathology. Whole slide imaging promises numerous advantages; however, adoption is limited by challenges in ease of use and speed of high-quality image rendering relative to the simplicity and visual quality of glass slides. Herein, we introduce Iris, a new high-performance digital pathology rendering system.

View Article and Find Full Text PDF

The COVID-19 pandemic highlighted the need for rapidly deployable, flexible vaccine platforms; particularly RNA which is now being explored for several other pathogens. DNA vaccines have potential advantages over RNA, including cost of manufacture, ease of storage and potentially lower reactogenicity. However, they have historically underperformed in large animals and human trials due to low immunogenicity.

View Article and Find Full Text PDF

Recent advancements in three-dimensional (3D) cell culture technologies, such as cell spheroids, organoids, and 3D bioprinted tissue constructs, have significantly improved the physiological relevance of in vitro models. These models better mimic tissue structure and function, closely emulating in vivo characteristics and enhancing phenotypic analysis, critical for basic research and drug screening in personalized cancer therapy. Despite their potential, current 3D cell culture platforms face technical challenges, which include user-unfriendliness in long-term dynamic cell culture, incompatibility with rapid cell encapsulation in biomimetic hydrogels, and low throughput for compound screening.

View Article and Find Full Text PDF

MEDOC: A Fast, Scalable, and Mathematically Exact Algorithm for the Site-Specific Prediction of the Protonation Degree in Large Disordered Proteins.

J Chem Inf Model

January 2025

Max-Planck-Institut für Immunbiologie und Epigenetik (MPI-IE), Stübeweg 51, 79108 Freiburg im Breisgau, Germany.

Intrinsically disordered regions are found in most eukaryotic proteins and are enriched with positively and negatively charged residues. While it is often convenient to assume that these residues follow their model-compound p values, recent work has shown that local charge effects (charge regulation) can upshift or downshift side chain p values with major consequences for molecular function. Despite this, charge regulation is rarely considered when investigating disordered regions.

View Article and Find Full Text PDF

For millennia mud has been utilized to make brick for the construction of both residential as well as architectural purposes. However, concerns regarding their vulnerability to different kinds of hazards due to their weak mechanical properties and durability have emerged. This study addressed the global challenge of developing sustainable and affordable construction materials, particularly in resource-constrained regions.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!