Primary sclerosing cholangitis is a complex pathological condition, characterized by chronic inflammation and fibrosis of the biliary epithelium. Without proper clinical management, progressive bile ducts and liver damage lead to cirrhosis and, ultimately, to liver failure. The known limited role of current drugs for treating this cholangiopathy has driven researchers to assess alternative therapeutic options. Some herbal remedies and their phytochemicals have shown anti-fibrotic properties in different experimental models of hepatic diseases and, occasionally, in clinical trials in primary sclerosing cholangitis patients; however their mechanism of action is not completely understood. This review briefly examines relevant studies focusing on the potential anti-fibrotic properties of , , , and quercetin. Each natural product is individually reviewed and the possible mechanisms of action discussed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298067PMC
http://dx.doi.org/10.3389/fphar.2020.00813DOI Listing

Publication Analysis

Top Keywords

primary sclerosing
12
sclerosing cholangitis
12
herbal remedies
8
anti-fibrotic properties
8
potentiality herbal
4
remedies primary
4
cholangitis clinical
4
clinical studies
4
studies primary
4
cholangitis complex
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!