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Symptom Monitoring App Use Associated With Medication Adherence Among Woman Survivors of Breast Cancer on Adjuvant Endocrine Therapy.
JCO Clin Cancer Inform
December 2024
Department of Radiation Oncology, Emory University, Atlanta, GA.
Purpose: Oral adjuvant endocrine therapy (AET) reduces the risk of cancer recurrence and death for women with hormone receptor-positive (HR+) breast cancer. Because of adverse symptoms and socioecologic barriers, AET adherence rates are low. We conducted post hoc analyses of a randomized trial of a remote symptom and adherence monitoring app to evaluate characteristics associated with higher app use, satisfaction, and how app use was associated with AET adherence.
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- The study aimed to determine if setting a lower mean arterial blood pressure (MAP) target could reduce 90-day all-cause mortality in critically ill patients with vasodilatory shock compared to a higher MAP target.
- Researchers performed a meta-analysis of randomized controlled trials involving 3,352 patients across several countries, using statistical models to analyze the data.
- The results suggested that a lower MAP target might be associated with a slight reduction in mortality risk, but the evidence is uncertain, indicating that it does not rule out the possibility of potential harm from lower targets.
Methylome-wide analysis in systemic microbial-induced experimental periodontal disease in mice with different susceptibility.
Front Cell Infect Microbiol
August 2024
Department of Oral & Maxillofacial Surgery and Periodontology, Ribeirão Preto Dental School, University of São Paulo - USP, Ribeirão Preto, São Paulo, Brazil.
Objective: The study delved into the epigenetic factors associated with periodontal disease in two lineages of mice, namely C57bl/6 and Balb/c. Its primary objective was to elucidate alterations in the methylome of mice with distinct genetic backgrounds following systemic microbial challenge, employing high-throughput DNA methylation analysis as the investigative tool.
Methods: ()was orally administered to induce periodontitis in both Balb/c and C57bl/6 lineage.
Anaphylactoid reactions during implantation of polymer-filled ring stent grafts for treatment of abdominal aortic aneurysms.
J Vasc Surg Cases Innov Tech
October 2024
Division of Vascular Surgery, CHU de Québec, Québec, Canada.
Polymer ring stent grafts from Endologix are reliable to treat challenging abdominal aortic aneurysm anatomy (hostile neck and tortuous or narrow iliac arteries). Rare cases of anaphylactoid reactions have been reported during the filing time of the graft rings due to polymer leakage. Management with amines, an antihistamine drug, and supportive care quickly stabilized both of our patients, which permitted the continuation and completion of their surgery.
View Article and Find Full Text PDFVaccination with folate receptor-alpha peptides in patients with ovarian cancer following response to platinum-based therapy: A randomized, multicenter clinical trial.
Gynecol Oncol
October 2024
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America. Electronic address:
Objective: Folate receptor alpha (FRα) is overexpressed on >90% of high-grade epithelial ovarian cancers (EOC). Targeting FRα with antibody-drug conjugates has proven utility in the platinum-resistant setting. It is also a potential therapeutic target for immuno-oncologic agents, such as peptide vaccines that work primarily via adaptive and humoral immunity.
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