Mycotoxins from the genus are widely known to cause economic losses in crops, as well as high mortalities rates among immunocompromised humans. However, to date, no correlation has been established for the ability of to cause cross-kingdom infection between plants and humans. The present investigation aims to fill this gap in the literature by examining cross-kingdom infection caused by strains isolated from non-immunocompromised or non-immunosuppressed humans, which were subsequently reinfected in plants and on human tissue. The findings document for the first time cross-kingdom infective events in species, thus enhancing our existing knowledge of how mycopathogens continue to thrive in different hosts.
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http://dx.doi.org/10.3390/microorganisms8060947 | DOI Listing |
Dev Cell
December 2024
State Key Laboratory of Hybrid Rice, College of Life Sciences, Wuhan University, Wuhan 430072, China; Hubei Hongshan Laboratory, Wuhan 430072, China. Electronic address:
The exchange of molecular information across kingdoms is crucial for the survival of both plants and their pathogens. Recent research has identified that plants transfer their small RNAs and microRNAs into fungal pathogens to suppress infection. However, whether and how plants send defense proteins into pathogens remains unknown.
View Article and Find Full Text PDFJ Cell Biochem
December 2024
Department of Biotechnology, National Institute of Technology, Durgapur, India.
Staphylococcus aureus is a major threat to human health, causing infections that range in severity from moderate to fatal. The rising rates of antibiotic resistance highlight the critical need for new therapeutic techniques to combat this infection. It has been recently discovered that microRNAs (miRNAs) are essential for cross-kingdom communication, especially when it comes to host-pathogen interactions.
View Article and Find Full Text PDFMicroorganisms
October 2024
College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China.
Biosens Bioelectron
February 2025
Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, United States. Electronic address:
Infectious diseases caused by pathogenic bacteria and fungi continuously pose a significant threat worldwide. The occurrence of polymicrobial infections, including polybacterial, polyfungal or bacteria-fungal co-infections further complicates diagnosis and treatment. Current diagnostic methods, heavily reliant on culture methods, are slow and often inefficient.
View Article and Find Full Text PDFTrends Immunol
December 2024
Department of Integrative Biology, University of California, Berkeley, CA, USA; San Francisco Chan Zuckerberg Biohub, San Francisco, CA, USA.
Following on from the discovery that innate immune pathways are shared widely across the tree of life comes another surprise: Hobbs et al. show that viruses targeting animals and bacteria also use highly conserved tools to fight back. Why such mechanisms remain seemingly unchanged despite the rapid coevolution among hosts and pathogens is now a key open question for the field.
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