AI Article Synopsis
- A new protoilludane-type sesquiterpene (mucoroidiol) and a geranylated bicyclogermacranol (firmibasiol) were isolated from cellular slime molds and their structures were determined using various spectral methods.
- Mucoroidiol and firmibasiol are the first reported modified and oxidized terpenoids from these organisms.
- Mucoroidiol exhibited moderate activity in inhibiting osteoclast differentiation, indicating that cellular slime molds may offer a rich source of unique secondary metabolites with potential applications in natural product chemistry.
Article Abstract
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356884 | PMC |
| http://dx.doi.org/10.3390/molecules25122895 | DOI Listing |
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