AI Article Synopsis
- Polyphenol intake is linked to changes in the gut microbiome and may improve metabolic health, independently of dietary fiber consumption.
- A study of over 1,800 UK women and 64 UK men showed that higher polyphenol consumption correlates with increased diversity in gut bacteria and a lower prevalence of obesity.
- The results suggest that gut microbiome diversity mediates about 11% of the relationship between polyphenol intake (specifically flavonoids and stilbenes) and obesity, indicating their importance for overall health.
Article Abstract
Background: Polyphenol consumption is implicated in gut microbiome composition and improved metabolic outcomes, but it is unclear whether the effect is independent of dietary fiber.
Methods: We investigated the links between (poly)phenol intake, gut microbiome composition (16s RNA) and obesity independently of fiber intake in UK women ( = 1810) and in a small group of UK men ( = 64).
Results: (Poly)phenol intakes correlated with microbiome alpha diversity (Shannon Index) after adjusting for confounders and fiber intake. Moreover, flavonoid intake was significantly correlated with the abundance of , (a genus known to improve physical performance), and stilbene intake with that of butyrate-producing bacteria ( and . Stilbene and flavonoid intake also correlated with lower odds of prevalent obesity ( Odds Ratio (95% Confidence Interval) (OR(95%CI)) = 0.80 (0.73, 0.87), = 4.90 × 10; : OR(95%CI) = 0.77 (0.65, 0.91), = 0.002). Formal mediation analyses revealed that gut microbiome mediates ~11% of the total effect of flavonoid and stilbene intake on prevalent obesity.
Conclusions: Our findings highlight the importance of (poly)phenol consumption for optimal human health.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353284 | PMC |
| http://dx.doi.org/10.3390/nu12061871 | DOI Listing |
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