Platelet-rich plasma (PRP) has recently become a popular treatment for various skin conditions, including striae distensae, acne scars, traumatic scars, hair regrowth, and cutaneous rejuvenation. Although PRP has been utilized in orthopedics for many years, its recent entry into dermatology has been met with controversy. While the recent research has generally been limited and is often contradictory, this has differed from the persuasive marketing campaigns targeting patients and consumers. Aesthetic practitioners should be knowledgeable with the available evidence for PRP in the treatment of striae distensae. Here, we review the pertinent literature and offer additional insights.
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Effectiveness of Fractional CO2 Laser and Topical Combination Therapy in Striae Distensae (Stretch Marks).
J Lasers Med Sci
November 2024
Faculty of Medicine Universitas Sriwijaya, Department of Dermatology, Venereology, and Aesthetics, Palembang, South Sumatra, Indonesia.
Striae distensae (SD) are a skin disorder characterized by linear atrophic depression of the dermis due to stretching of the skin. There are various SD therapy modalities, namely topical therapy, peeling, microneedling, platelet-rich plasma, and laser. Until now, there has been no standard therapy for SD, but several therapeutic modalities can reduce clinical symptoms, so knowledge about the current management of SD is needed.
View Article and Find Full Text PDFComparative study of microneedling monotherapy versus microneedling with autologous platelet-rich plasma for the treatment of stretch marks (striae distensae) and post-surgical scars: Clinical and dermoscopy outcomes.
J Cutan Aesthet Surg
October 2024
Department of Dermatology, Leprosy and Venereology, Government Medical College, Faridkot, Punjab, India.
Article Synopsis
- The study aimed to compare the effectiveness and safety of microneedling alone versus microneedling combined with autologous platelet-rich plasma (PRP) for treating stretch marks and post-surgical scars.
- A total of 30 participants were divided into two groups, with one group receiving only microneedling and the other receiving microneedling plus PRP, assessed for improvement over 20 weeks.
- Results showed significant aesthetic improvement and higher satisfaction rates in the PRP group compared to the microneedling-only group, with no major side effects reported.
Effects of Nanofat and PRP on Type I Collagen Production in Striae Distensae: Preliminary Findings from a Prospective, Randomized Single-Blind Study.
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Department of Plastic, Reconstructive and Maxillo facial Surgery, Henri Mondor Hospital, University Paris XII, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France.
Introduction: Striae distensae (SD) appear clinically as parallel striae, lying perpendicular to the tension lines of the skin. SD evolve into two clinical phases, an initial inflammatory phase in which they are called "striae rubrae" (SR) and a chronic phase in which they are called striae albae (SA). This study investigates the synergistic effect of nanofat and platelet-rich plasma (PRP) injections on collagen production in fibroblasts derived from SA (SAF).
View Article and Find Full Text PDFEfficacy of dermapen combined with topical insulin versus dermapen combined with topical hyaluronic acid in treatment of stretch marks: comparative study.
Arch Dermatol Res
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Dermatology and Venereology Department, Faculty of Medicine (Girls), Al-Azhar University, 53, New Cairo, 3rd Zone Fifth, Settlement, Cairo, Egypt.
Striae distensae (SD) are visible linear scars developing in areas of dermal damage. Insulin is a peptide hormone that can potentially help restore the integrity of damaged skin and promote the reformation of granulation tissue. Hyaluronic Acid is commonly used in aesthetic medicine.
View Article and Find Full Text PDFComparing fractional microneedle radiofrequency and fractional CO2 laser for striae distensae treatment: a systematic review and meta-analysis.
Lasers Med Sci
November 2024
Nazan Yilmaz Dermatology Clinic, Istanbul, Turkey.
Striae distensae (SD) are a prevalent dermatological concern of women and approximately 90% of pregnant women experience these stretch marks. Fractional microneedle radiofrequency (FMR) and fractional CO2 laser (FCL) have gained substantial attention in the treatment of SD. In clinical studies, a clear superiority between FMR and FCL treatments is not found due to limited studies and sample sizes.
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