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Drug-induced sleep endoscopy (DISE) is a procedure for the assessment of the upper airways in patients with obstructive sleep apnea (OSA) and was first described by Croft and Pringle in 1991 1. So far, it has not been clarified to what extent the DISE can be compared to natural sleep. Eastwood and colleagues ultimately described a correlation in terms of the tendency to collapse in sedation and during natural sleep. It was shown, that DISE is useful in individual therapeutic descisions 2. In recent years, efforts to standardize the procedure have been made in order to make the results more comparable and reproducible. With the introduction and increasing use of stimulation therapy of the hypoglossal nerve, DISE has been used more and more in hospitals in recent years. This article is intended to present the procedure based on the European position paper on DISE 3 4.
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http://dx.doi.org/10.1055/a-1157-9398 | DOI Listing |
Adv Sci (Weinh)
March 2025
Department of Neurobiology, Hebei Medical University, Shijiazhuang, 050017, China.
The dynamic interaction between central respiratory chemoreceptors and the respiratory central pattern generator constitutes a critical homeostatic axis for stabilizing breathing rhythm and pattern, yet its circuit-level organization remains poorly characterized. Here, the functional connectivity between two key medullary hubs: the nucleus tractus solitarius (NTS) and the preBötzinger complex (preBötC) are systematically investigated. These findings delineate a medullary network primarily comprising Phox2b-expressing NTS neurons (NTS), GABAergic NTS neurons (NTS), and somatostatin (SST)-expressing preBötC neurons (preBötC).
View Article and Find Full Text PDFBrain Behav Immun
March 2025
Department of Behavioural Science and Health, Institute of Epidemiology and Health Care, University College London, 1-19 Torrington Place, London WC1E 7HB, UK.
Background: Proinflammatory and neuroendocrine mediators are implicated in disease aetiopathogenesis. Stress increases concentrations of immune-neuroendocrine biomarkers through a complex network of brain-body signalling pathways. Suboptimal sleep further modulates these processes by altering major effector systems that sensitise the brain to stress.
View Article and Find Full Text PDFAnal Chem
March 2025
Department of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio 43210, United States.
The lipidome, encompassing the comprehensive lipid fingerprint of a biological system, includes thousands of unique isomeric and isobaric lipid species. Mass spectrometry (MS) is an effective technique for characterizing the lipidome, although the resolution of isomeric lipid species through MS typically requires specialized or modified equipment. In this study, we introduce a novel matrix derivatization technique that leverages the unique photoreactive properties of unsaturated lipids to reveal the double-bond location in conventional matrix-assisted laser desorption-ionization mass spectrometry (MALDI-MS) experiments.
View Article and Find Full Text PDFJ Sleep Res
March 2025
Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia.
Post-traumatic stress disorder (PTSD) is a highly debilitating condition that develops after trauma exposure. Dysregulation in extinction memory consolidation (i.e.
View Article and Find Full Text PDFJ Assoc Physicians India
March 2025
Professor, Department of Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India, Orcid: https://orcid.org/0000-0001-6336-5179.
Background: Functional dyspepsia (FD) is one of the most common reasons for medical visits. Patients with FD incur large direct and indirect expenditures and may have significant financial burdens that affect quality of life. Our study aimed to assess the effectiveness of meditation as an adjuvant to the standard treatment in individuals diagnosed with FD.
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