Background: The rapid diagnosis of Coronavirus Disease 2019 (COVID-19) patients is essential to reduce the disease spread. Rapid antigen detection (RAD) tests are available, however, there is scanty data on the performance of RAD tests.
Objective: To evaluate the performance of the commercially available BIOCREDIT COVID-19 Ag test and compare it with RT-PCR for detecting Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. Analytical sensitivity for the detection of SARS-CoV-2 virus was determined for the RAD test using viral culture and RT-PCR as reference methods. The RAD test was further evaluated using respiratory samples collected from confirmed COVID-19 patients. The results were compared with RT-PCR test.
Results: The detection limits between RAD test, viral culture and RT-PCR varied hugely. RAD was 10 fold less sensitive than viral culture while RAD was 10 fold less sensitive than RT-PCR. The RAD test detected between 11.1 % and 45.7 % of RT-PCR-positive samples from COVID-19 patients.
Conclusions: This study demonstrated that the RAD test serves only as adjunct to RT-PCR test because of potential for false-negative results.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278630 | PMC |
| http://dx.doi.org/10.1016/j.jcv.2020.104500 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association of Vitamin D and Prostate Health Status in Men: An Analytical Cross-Sectional Study.
Cureus
December 2024
General Medicine, Sri Ramaswamy Memorial Medical College Hospital and Research Centre, Sri Ramaswamy Memorial Institute of Science and Technology, Kattankulathur, IND.
Article Synopsis
- Benign prostatic hyperplasia (BPH) is the leading cause of lower urinary tract symptoms, and the study explores how vitamin D's anti-inflammatory properties might help alleviate these symptoms.
- The research involved men aged 45 to 80 with urinary issues, categorizing them based on their prostate-specific antigen (PSA) levels to assess the link between vitamin D levels and prostate health.
- Results indicated that PSA levels rise with age, particularly in men over 60, and a negative correlation between PSA and vitamin D levels was found in men aged 60 to 69.
Prognostic Value of / Status for Overall Survival in First-Line Monoimmunotherapy and Chemoimmunotherapy Treated Patients With Nonsquamous NSCLC in the Netherlands: A Brief Report.
JTO Clin Res Rep
December 2024
Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Introduction: Programmed death-ligand 1 (PD-L1) is the main predictive biomarker used to identify patients with NSCLC who are eligible for treatment with immune checkpoint inhibitors. Despite its utility, the predictive capacity of PD-L1 is limited, necessitating the exploration of supplementary predictive biomarkers. In this report, we describe the prognostic value of / mutation status for overall survival (OS) in patients with NSCLC treated with first-line immunotherapy or combined chemoimmunotherapy.
View Article and Find Full Text PDFEffect of different custom-made foot orthotics on foot joint stiffness in individuals with structural hallux limitus: A quasi-experimental study.
Clin Biomech (Bristol)
December 2024
Facultad de Enfermería y Podología, Universidad de Valencia, C/Jaume Roig s/n, 46010, Valencia, Spain. Electronic address:
Background: Normal dorsiflexion of the first metatarsophalangeal joint during dynamic activities is critical for effective propulsion. Therapeutic foot orthotics may address the pathomechanical loading and joint kinematics issues faced by this population. This study aims to evaluate the effect of two different types of Custom-made foot orthosis compared to shod condition on the stiffness of the rearfoot, midfoot, and 1st metatarsophalangeal joint during walking in patients with Structural Hallux Limitus.
View Article and Find Full Text PDFA Tale of Two Lakes: Divergent Evolutionary Trajectories of Two Populations Experiencing Distinct Environments.
Ecol Evol
December 2024
Program in Ecology and Evolutionary Biology, School of Biological Sciences University of Oklahoma Norman Oklahoma USA.
Most studies of local adaptation substitute the correlation between spatial distance and environmental heterogeneity for the temporal dynamics over which local adaptation evolves. The availability of detailed ecological and genomic information from lake sediments provides an opportunity to study local adaptation with unparalleled clarity from the temporal perspective. Inference can be further enhanced by including multiple lakes along ecological axes to further isolate the effects of ecological change in driving local adaptation.
View Article and Find Full Text PDFA Fusion Model of MRI Deep Transfer Learning and Radiomics for Discriminating between Pilocytic Astrocytoma and Adamantinomatous Craniopharyngioma.
Acad Radiol
December 2024
Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (Y.M., X.K., Y.L., F.X., Y.L., J.M.). Electronic address:
Rationale And Objectives: This study aimed to develop and validate a fusion model combining MRI deep transfer learning (DTL) and radiomics for discriminating between pilocytic astrocytoma (PA) and adamantinomatous craniopharyngioma (ACP) in the sellar region.
Methods: This study included 348 patients with histologically confirmed PA (n = 139) and ACP (n = 209). Data were randomly divided into training and testing cohorts in a 7:3 ratio.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!