[This corrects the article DOI: 10.1371/journal.pone.0228156.].
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316306 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235547 | PLOS |
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CalPen (Calculator of Penetrance), a web-based tool to estimate penetrance in complex genetic disorders.
PLoS One
April 2020
Department of Biological Sciences, Hyderabad, India.
Mutations conferring susceptibility to complex disorders also occur in healthy individuals but at significantly lower frequencies than in patients, indicating that these mutations are not completely penetrant. Therefore, it is important to estimate the penetrance or the likelihood of developing a disease in presence of a mutation. Recently, a method to calculate penetrance and its credible intervals was developed on the basis of the Bayesian method and since been used in literature.
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