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| http://dx.doi.org/10.1503/jpn.2045302 | DOI Listing |
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Mental Health Care Utilization and Prescription Rates Among Children, Adolescents, and Young Adults in France.
JAMA Netw Open
January 2025
CEReSS, Research Centre on Health Services and Quality of Life, Aix Marseille University, Marseille, France.
Importance: Amid escalating mental health challenges among young individuals, intensified by the COVID-19 pandemic, analyzing postpandemic trends is critical.
Objective: To examine mental health care utilization and prescription rates for children, adolescents, and young adults before and after the COVID-19 pandemic.
Design, Setting, And Participants: This population-based time trend study used an interrupted time series analysis to examine mental health care and prescription patterns among the French population 25 years and younger.
Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study.
PLoS Med
December 2024
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR.
Background: Clozapine is widely regarded as a highly efficacious psychotropic drug that is largely underused worldwide. Recent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use and hematological malignancy (HM). Nevertheless, the absolute rate difference is not well-established due to the absence of analytic cohort studies.
View Article and Find Full Text PDFMulti-level barriers and facilitators to implementing evidence-based antipsychotics in the treatment of early-phase schizophrenia.
Front Health Serv
October 2024
Department of Psychiatry and Behavioral Sciences and Center for Dissemination and Implementation Science, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Introduction: Long-acting injectable (LAI) antipsychotic medications and clozapine are effective yet underutilized medical therapies in early intervention services. The purpose of this study was to conduct a pre-implementation evaluation of contextual determinants of early intervention programs to implement innovations optimizing LAI antipsychotic and clozapine use within a shared decision-making model.
Methods: Semi-structured interviews explored barriers and facilitators to implementing LAI antipsychotics and clozapine in early intervention services.
Antipsychotic exposure and infection risk in people with schizophrenia spectrum disorders during the COVID-19 pandemic: a Danish nationwide registry study.
Lancet Psychiatry
October 2024
Copenhagen Research Center for Biological and Precision Psychiatry, Mental Health Centre Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Background: Infection risk and mortality are increased in schizophrenia spectrum disorders, which was corroborated during the COVID-19 pandemic. However, evidence is lacking regarding the additional impact of antipsychotic drugs, and the highly debated safety of clozapine treatment during large-scale infection outbreaks. Therefore, we aimed to investigate risk of COVID-19 and non-COVID respiratory infections during exposure to antipsychotics.
View Article and Find Full Text PDFThe impact of COVID-19 public health measures on the utilization of antipsychotics in schizophrenia in Manitoba - A population-based study.
Schizophr Res
October 2024
College of Pharmacy, University of Manitoba, Winnipeg, Canada; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. Electronic address:
Article Synopsis
- The study investigated how COVID-19 public health measures impacted access to antipsychotic medications for individuals with schizophrenia in Manitoba, Canada.
- During the initial months of the pandemic (April-June 2020), there was a notable decline in new prescriptions for antipsychotics, even though overall usage remained stable compared to previous years.
- The findings highlight the need for further research on how changes in medication access during the pandemic may affect outcomes for people with schizophrenia, which could inform future public health strategies.
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