AI Article Synopsis
- The Brain Health Assessment-Cognitive Score (BHA-CS) was developed to assess cognitive health and monitor disease progression in older adults, both cognitively normal and those with cognitive impairments.
- Through a study involving over 800 participants, the BHA-CS demonstrated strong reliability and identified cognitive decline effectively, detecting significant changes in 75% of dementia patients and 44% of those with mild cognitive impairment.
- The assessment also revealed that cognitively normal individuals with higher amyloid beta levels performed worse on the BHA-CS over time, indicating its utility in early detection of neurodegenerative diseases.
Article Abstract
Introduction: Composite scores based on psychometrically rigorous cognitive assessments are well suited for early diagnosis and disease monitoring.
Methods: We developed and cross-validated the Brain Health Assessment-Cognitive Score (BHA-CS), based on a brief computerized battery, in 451 cognitively normal (CN) and 399 cognitively impaired (mild cognitive impairment [MCI] or dementia) older adults. We investigated its long-term reliability and reliable change indices at longitudinal follow-up (N = 340), and the association with amyloid beta (Aβ) burden in the CN subgroup with Aβ positron emission tomography (N = 119).
Results: The BHA-CS was accurate at detecting cognitive impairment and exhibited excellent long-term stability. Reliable decline over one year was detected in 75% of participants with dementia, 44% with MCI, and 3% of CN. Among CN, the Aβ-positive group showed worse longitudinal performance on the BHA-CS compared to the Aβ-negative group.
Discussion: The BHA-CS is sensitive to cognitive decline in preclinical and prodromal neurodegenerative disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306517 | PMC |
| http://dx.doi.org/10.1002/dad2.12042 | DOI Listing |
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