Genetic Variations and Frequencies of the Two Functional Single Nucleotide Polymorphisms of in the Thai Population.

Aim: To investigate the variations and the frequencies of the gene in the Thai population.

Methods: Collected samples were categorized into five regions of Thailand. DNA samples were genotyped for two variants, c.388A>G and c.521T>C of the using TaqMan real-time PCR.

Results: The minor allele frequencies (MAFs) of two single nucleotide polymorphisms (SNPs) were not significantly different among the five regions. The most frequent haplotype was (frequency: 0.654), followed by (frequency: 0.217), (frequency: 0.128), and (frequency: 0.001). We observed a similar frequency of OATP1B1 transporter phenotypes compared to other populations. 75.85% of the Thai subjects showed normal OATP1B1 activity, 22.5% showed intermediate OATP1B1 activity, and 1.58% showed low OATP1B1 activity.

Conclusion: This study reported the frequencies of the variants and the subsequent OATP1B1 activity in a large cohort of Thais that can provide important information for the guidance of personalized drug therapy.