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Distinctive Subpopulations of Stromal Cells Are Present in Human Lymph Nodes Infiltrated with Melanoma. | LitMetric

AI Article Synopsis

  • Metastasis of tumors to lymph nodes is a bad sign for patient prognosis, as it can suppress immune responses that fight cancer.
  • This study identifies two unique populations of stromal cells (SCs) in melanoma-infiltrated lymph nodes, one acting like fibroblastic reticular cells that help modulate T-cell responses, and the other being a new type of SC that primarily produces extracellular matrix.
  • By distinguishing these SC subpopulations from other cell types, researchers can better understand how they affect T-cell reactions to tumors and the overall clinical outcomes for patients.

Article Abstract

Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play a crucial role in enabling T-cell responses, and because tumor metastases modulate their structure and function, this interaction may suppress immune responses to tumor antigens. The SC subpopulations that respond to infiltration of malignant cells into human LNs have not been defined. Here, we identify distinctive subpopulations of CD90 SCs present in melanoma-infiltrated LNs and compare them with their counterparts in normal LNs. The first population (CD90 podoplanin CD105 CD146 CD271 VCAM-1 ICAM-1 α-SMA) corresponds to fibroblastic reticular cells that express various T-cell modulating cytokines, chemokines, and adhesion molecules. The second (CD90 CD34 CD105 CD271) represents a novel population of CD34 SCs embedded in collagenous structures, such as the capsule and trabeculae, that predominantly produce extracellular matrix. We also demonstrated that these two SC subpopulations are distinct from two subsets of human LN pericytes, CD90 CD146 CD36 NG2 pericytes in the walls of high endothelial venules and other small vessels, and CD90 CD146 NG2 CD36 pericytes in the walls of larger vessels. Distinguishing between these CD90 SC subpopulations in human LNs allows for further study of their respective impact on T-cell responses to tumor antigens and clinical outcomes.

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Source
http://dx.doi.org/10.1158/2326-6066.CIR-19-0796DOI Listing

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