We report a palladium-catalyzed, three-component carbosilylation reaction of internal symmetrical alkynes, silicon electrophiles, and primary alkyl zinc iodides. Depending on the choice of ligand, stereoselective synthesis of either or -tetrasubstituted vinyl silanes is possible. We also demonstrate conditions for the Hiyama cross-coupling of these products to prepare geometrically defined tetrasubstituted alkenes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405989 | PMC |
| http://dx.doi.org/10.1021/jacs.0c05382 | DOI Listing |
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