AI Article Synopsis
- Up to 10% of patients with lichen planus experience nail involvement, but there are few studies on its histopathological features, with nail biopsy being the standard diagnostic method.
- A study involving 45 patients with nail lichen planus revealed a mean age of 36.91 years, with the most common clinical variant being oral LP; notable symptoms included onychorrhexis and longitudinal melanonychia.
- Histopathological analysis showed common features like hypergranulosis and sawtooth acanthosis, while a new finding of "fraying of nail plate" was noted in a significant number of cases, indicating that current diagnostic criteria for nail LP need improvement.
Article Abstract
Introduction: Up to 10% of patients with lichen planus (LP) have nail involvement; still there is a paucity of studies on histopathological features. Nevertheless, nail biopsy is the diagnostic standard, especially for isolated nail LP.
Methodology: Nails of 45 patients with nail LP were evaluated clinically and biopsies taken from most involved nail (25 nail bed and 20 matrix biopsies). Correlation of clinical and histopathological features was also done.
Results: The mean age of the study group participants was 36.91 ± 18.27 years with a M:F ratio of 1.81:1. The most common clinical variant of LP seen was oral LP (51%), with isolated nail involvement in 29%. Clinically, major features were onychorrhexis (92.3%), longitudinal melanonychia (74.3%), and nail bed erythema (54%). Histopathologically, hypergranulosis of nail matrix and bed epithelium (51.1%), followed by sawtooth acanthosis (44.4%) and lichenoid band (24.4%) were most common. A diagnosis using prevalent diagnostic criteria was confirmed in 51.1% biopsies. Distinctive "fraying of nail plate," a change not previously described, was noted in 33.3% cases.
Conclusion: Histopathology of nail LP has been attributed a diagnostic role; however, existing diagnostic criteria are not sensitive enough and need refinement. Not hitherto described features like fraying of nail plate are seen in a significant number of cases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/cup.13783 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Introduction: Patients with end-stage renal disease usually undergo hemodialysis as a way of renal function replacement therapy which comes with a wide array of systemic and cutaneous complications. The aim of this study was to evaluate the most frequent dermatological manifestations including xerosis, pruritis and other nail, hair and oral conditions, as these are a very important aspect to be considered while managing the patients psychological and physical needs to improve their outcomes and quality of life.
Methods: This retrospective cross-sectional study was performed by selecting 77 patients on hemodialysis based on a certain criteria and data was then collected on a sheet using patients database on Hakeem National E-Health Program, in addition to information from interviews with patients during their hemodialysis sessions after taking an oral informed consent and insuring patients' privacy.
Implant waste and associated costs in trauma and orthopaedic surgery: a systematic review.
Int Orthop
January 2025
MSk Lab, Imperial College London, London, W12 0BZ, UK.
Purpose: Trauma and orthopaedic (T&O) surgery relies on medical implants and materials, often resulting in metalwork wastage (prosthesis, screws, nails, and plates). This places an economic strain on healthcare services and the environment. Our primary outcome is to quantify the implant wastage across the literature, and secondarily investigate the associated costs in this specialty.
View Article and Find Full Text PDFComparative finite element analysis: internal fixation plate versus intramedullary nail for neer type III-VI proximal humeral fractur.
J Orthop Surg Res
January 2025
Department of Orthopedics, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
Background: Finite element analysis (FEA) could advance the understanding of fracture fixation and guide the choice of surgical treatment. This study aimed to compare two internal fixation methods in the treatment of displaced proximal humeral fracture (PHF) through FEA.
Methods: Three-dimensional FEA model based on the left shoulder joint of a 67-year-old female patient with PHFs and osteoporosis was adopted, in order to analyze the fixation effect and load stress distribution of internal fixation plates with open reduction and intramedullary nails without opening the fracture in the treatment of Neer III-VI PHF.
Self-inflicted nail gun injury piercing the common peroneal nerve with no deficit: A case report.
Trauma Case Rep
December 2024
Department of Orthopaedic Surgery and Sports Medicine, Detroit Medical Center, Detroit, MI 48201, United States of America.
We present a case involving a 36-year-old male who experienced a nail gun injury to the posterolateral knee, leading to intraoperative nail removal. We observed bisection of the common peroneal nerve during the procedure with tethering, fortunately without any functional or sensory deficits.
View Article and Find Full Text PDFDeath associated protein kinase 1 dampens keratinocyte necroptosis and expression of inflammatory genes in lichen planus.
J Invest Dermatol
December 2024
Department of Dermatology and Allergy, Technical University of Munich, Munich, Germany; Department of Dermatology, Ludwig-Maximilians University Hospital, Munich, Germany. Electronic address:
Lichen planus (LP) is a chronic inflammatory disease (ISD) affecting skin, mucosa, nail, and hair. Previous studies demonstrated a pivotal role of type 1 immunity in LP, as infiltrating T cells trigger apoptosis and necroptosis in the epidermis. In this study, we investigated the role of DAPK1 in LP with special focus on its role in mediating cell death and inflammation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!