In this issue of , Thakore report that the Ca-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7384335 | PMC |
| http://dx.doi.org/10.1126/scisignal.abc0993 | DOI Listing |
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TRPML1ng on sparks.
Sci Signal
June 2020
Department of Pharmacology, University of California Davis, Davis, CA 95616, USA.
In this issue of , Thakore report that the Ca-permeable channel TRPML1 closely associates with ryanodine receptors to induce Ca sparks in native arterial myocytes. Functional studies revealed a key role for TRPML1 channels in regulation of arterial myocyte contractility and blood pressure.
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