The MeOH/CHCl (1:1) extracts of the roots and leaves of and showed potent antitrypanosomal activity during preliminary screening on . Phytochemical investigation of these extracts led to the isolation of a mixture of two new endiandric acid derivatives beilschmiedol B () and beilschmiedol C (), and one new phenylalkene obscurene A () together with twelve known compounds (-). In addition, four new derivatives (-) were synthesized from compound . Their structures were elucidated based on their NMR and MS data. Compounds , , and were isolated for the first time from the genus. Additionally, the NMR data of compound are given here for the first time. The isolates were evaluated for their antitrypanosomal and antimalarial activities against and the chloroquine-resistant strain in vitro, respectively. From the tested compounds, the mixture of new compounds and exhibited the most potent antitrypanosomal activity in vitro with IC value of 4.91 μM.
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| http://dx.doi.org/10.3390/molecules25122862 | DOI Listing |
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