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Background: For patients with osteoporosis and rotator cuff tears, there is still no consensus on current treatment methods. The material, structure, and number of anchors have important effects on the repair outcome.

Purpose: To investigate the use of chitosan quaternary ammonium salt-coated nickel-titanium memory alloy (NTMA) anchors to treat rotator cuff injury in shoulders with osteoporosis in a rabbit osteoporosis model.

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Donor MHC-specific thymus vaccination allows for immunocompatible allotransplantation.

Cell Res

January 2025

Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.

Organ transplantation is the last-resort option to treat organ failure. However, less than 10% of patients benefit from this only option due to lack of major histocompatibility complex (MHC)-matched donor organs and 25%-80% of donated organs could not find MHC-matched recipients. T cell allorecognition is the principal mechanism for allogeneic graft rejection.

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Introduction: Different Guided Tissue Regeneration (GTR) procedures, such as membranes, bone substitute materials, and Autologous Platelet Concentrates (APCs), have been applied after surgical root canal treatment (SRCT), which produce different outcomes. This study aimed to evaluate the impact of regenerative procedures on the healing process following SRCT.

Methods: A comprehensive search of PubMed, Embase, Scopus, Cochrane, and the Web of Science found Randomized Controlled Trials (RCTs) published until February 25, 2024.

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Clinical state and future directions of stem cell therapy in stroke rehabilitation.

Exp Neurol

December 2024

Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA, USA; Stanford Stroke Center, Stanford University School of Medicine, Stanford, CA, USA. Electronic address:

Despite substantial advances in the acute management of stroke, it remains a leading cause of adult disability and mortality worldwide. Currently, the reperfusion modalities thrombolysis and thrombectomy benefit only a fraction of patients in the hyperacute phase of ischemic stroke. Thus, with the exception of vagal nerve stimulation combined with intensive physical therapy, there are no approved neuroprotective/neurorestorative therapies for stroke survivors.

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Article Synopsis
  • B cells can be engineered to produce therapies for genetic disorders, metabolic diseases, and cancer.
  • A method was developed to collect, expand, differentiate, and track B cells from non-human primates (NHPs) using radioactively labeled imaging techniques.
  • The study showed that infused B cells successfully targeted the bone marrow, spleen, and liver without serious side effects, indicating the potential for repeated treatments and the viability of NHPs as a model for human B cell medicine research.
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