Ring vaccination is a mitigation strategy that consists in seeking and vaccinating the contacts of a sick patient, in order to provide immunization and halt the spread of disease. We study an extension of the susceptible-infected-recovered (SIR) epidemic model with ring vaccination in complex and spatial networks. Previously, a correspondence between this model and a link percolation process has been established, however, this is only valid in complex networks. Here, we propose that the SIR model with ring vaccination is equivalent to a mixed percolation process of links and nodes, which offers a more complete description of the process. We verify that this approach is valid in both complex and spatial networks, the latter being built according to the Waxman model. This model establishes a distance-dependent cost of connection between individuals arranged in a square lattice. We determine the epidemic-free regions in a phase diagram based on the wiring cost and the parameters of the epidemic model (vaccination and infection probabilities and recovery time). In addition, we find that for long recovery times this model maps into a pure node percolation process, in contrast to the SIR model without ring vaccination, which maps into link percolation.
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http://dx.doi.org/10.1103/PhysRevE.101.052309 | DOI Listing |
Comput Struct Biotechnol J
December 2024
National Vaccine Innovation Platform, Scholl of Pharmacy, Nanjing Medical University, Nanjing 211166, China.
Unlabelled: The prevention and treatment of metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), have emerged as critical global health challenges. Current lipid-lowering pharmacotherapies are associated with side effects, including hepatotoxicity, rhabdomyolysis, and decreased erythrocyte counts, underscoring the urgent need for safer therapeutic alternatives. Hepatocyte nuclear factor 4α (HNF4α) has been identified as a pivotal regulator of lipid metabolism, making it an attractive target for drug development.
View Article and Find Full Text PDFChembiochem
January 2025
Sun Yat-Sen University, School of Pharmaceutical Sciences (Shenzhen), 132, East Outer Ring Road, Panyu, 518107, Shenzhen, CHINA.
In clinical practice, thymopentin (TP-5) is a commonly utilized immunomodulatory peptide drug. The relatively short half-life of TP-5, however, significantly limits its applicability in immunotherapy. Inspired by the structure of the TLR2 ligand lipopeptide Pam3CSK4, fatty acid-modified TP-5 peptides were designed and synthesized in this study.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
End-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days compared to a dapivirine-only ring (DVR-200mg) in MTN-030/IPM 041 (n = 23), and when used for 90 days cyclically or continuously in MTN-044/IPM 053/CCN019 (n = 25). We enrolled healthy, non-pregnant, HIV-negative women aged 18-45 in Pittsburgh, PA and Birmingham, AL (MTN-030 only).
View Article and Find Full Text PDFInt J Infect Dis
January 2025
Department of Biostatistics, University of Florida, Gainesville, USA. Electronic address:
Objectives: Assess the effectiveness of ring vaccination in controlling an Ebola virus outbreak in the Democratic Republic of Congo.
Methods: This analysis focuses on two areas of the Democratic Republic of Congo, Beni and Butembo/Katwa, which were affected during the 2018-2020 Ebola outbreak. To simulate Ebola virus transmission, we used a spatially explicit agent-based model with households, health care facilities, and Ebola treatment units.
Mikrochim Acta
January 2025
Shanxi Key Laboratory of Micro Nano Sensors & Artificial Intelligence Perception, College of Integrated Circuits, Taiyuan University of Technology, Taiyuan, 030024, China.
African swine fever (ASF) is an acute hemorrhagic disease in pigs caused by the African swine fever virus (ASFV), which has a high mortality rate and brought great damage to global pig farming industry. At present, there is no effective treatment or vaccine to combat ASFV infection, so early detection of ASFV has become particularly important. Therefore, the PDMS/chitosan/MPMs composite film was proposed to detect ASFV P72.
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