Background: Coronavirus disease 2019 (COVID-19) is posing a huge threat to human health worldwide. We aim to investigate the immune status of CD8 T and NK cells in COVID-19 patients.
Methods: The count and immune status of lymphocytes were detected by flow cytometry in 32 COVID-19 patients and 18 healthy individuals.
Results: As the disease progression in COVID-19 patients, CD8 T and NK cells were significantly decreased in absolute number but highly activated. After patients' condition improved, the count and immune status of CD8 T and NK cells restored to some extent. GrACD8 T and perforin NK cells had good sensitivity and specificity for assisting diagnosis of COVID-19.
Conclusions: As the disease progression, the declined lymphocytes in COVID-19 patients might lead to compensatory activation of CD8 T and NK cells. GrACD8 T and perforin NK cells might be used as meaningful indicators for assisting diagnosis of COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305921 | PMC |
| http://dx.doi.org/10.1016/j.clim.2020.108516 | DOI Listing |
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