Lichens, a natural source producing a number of valuable compounds is economically not feasible and profitable due to its slow growth. Mycobiont cultures are alternative sources which have become highly attractive for chemists recently. Mycobiont of sp., a native lichens in Vietnam was separated then cultivated in test tubes. The present study aimed to identify chemical constituents of the cultured mycobiont of sp. Multiple chromatographic methods were applied to isolate three eremophilane sesquiterpenes including one new compound, graphilane () and two known compounds sporogen-AO-1 () and dihydrosporogen-AO-1 (). Their chemical structures was elucidated by extensive 1 D and 2 D NMR analysis and high resolution mass spectroscopy as well as comparisons in literature. Compound was evaluated for the cytotoxic activity against K562 cancer cell line and revealed moderate activity with IC value of 87.20 ± 0.76 µM.
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