AI Article Synopsis
- Rheumatoid arthritis (RA) leads to joint damage if untreated, and is linked to primary biliary cholangitis (PBC), a liver autoimmune disease.
- A case study of a 76-year-old man with both PBC and RA showed that tocilizumab, a treatment for RA, effectively managed both conditions.
- This suggests that tocilizumab could be a safe and effective option for RA patients with PBC, possibly due to its role in inhibiting IL-6.
Article Abstract
Rheumatoid arthritis (RA) is characterized by synovitis of multiple joints which if untreated progresses to joint destruction. Primary biliary cholangitis (PBC) is an autoimmune and progressive disease of the liver of unknown origin. About 1.8-5.6% of individuals with PBC have RA and patients with RA are at higher risk of developing PBC compared to the general population. We report a case of a 76-year-old man, with a history of PBC, and a recent RA diagnosis, in which tocilizumab therapy was effective in the control of RA and PBC, and a literature review was performed. This case, along with only one case published in literature in which tocilizumab was used in the treatment of RA and PBC, suggests that tocilizumab may be effective and safe in the treatment of RA in patients with PBC. Inhibition of IL-6 may also be effective in PBC treatment.
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| http://dx.doi.org/10.1016/j.reuma.2020.04.014 | DOI Listing |
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