This study investigated the adjuvant effects for anticancer and antifatigue of the combination of extract with sorafenib. The 5 extracts of were obtained through hexane, chloroform, ethyl acetate, butanol, and water and were evaluated for anticancer growth activity. Among these extracts, ethyl acetate extract of showed the best tumor growth inhibitory activity and the adjuvant effects in combination with sorafenib. As a result of biochemical analysis with serum, the combination of ethyl acetate extract of with sorafenib showed the adjuvant effects both improving hepatic function and relieving cancer-related fatigue. In addition, H-nuclear magnetic resonance-based metabolic profiling in liver tissues showed that the change of metabolism by ethyl acetate extract of with sorafenib was related with serum fatigue biomarkers. Therefore, the combination strategy such as ethyl acetate extraction of with sorafenib constitutes a promising therapeutic strategy in hepatocellular carcinoma, via the inhibition of cancer growth, the enhancement of liver function, as well as the alleviation of cancer-related fatigue.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313340 | PMC |
| http://dx.doi.org/10.1177/1534735420932635 | DOI Listing |
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