Association between Five Common Plasminogen Activator Inhibitor-1 () Gene Polymorphisms and Colorectal Cancer Susceptibility.

The plasminogen activator inhibitor-1 () is expressed in many cancer cell types and modulates cancer growth, invasion, and angiogenesis. The present study investigated the association between five gene polymorphisms and colorectal cancer (CRC) risk. Five polymorphisms (-844G > A [rs2227631], -675 4G > 5G [rs1799889], +43G > A [rs6092], +9785G > A [rs2227694], and +11053T > G [rs7242]) were genotyped using a polymerase chain reaction-restriction fragment length polymorphism assay in 459 CRC cases and 416 controls. Increased CRC risk was more frequently associated with -675 5G5G polymorphism than with 4G4G (adjusted odds ratio (AOR) = 1.556; 95% confidence interval (CI): 1.012-2.391; = 0.04). In contrast, for the +11053 polymorphism, we found a lower risk of CRC with the GG genotype (AOR = 0.620; 95% CI: 0.413-0.932; = 0.02) than with the TT genotype, as well as for recessive carriers (TT + TG vs. GG, AOR = 0.662; 95% CI: 0.469-0.933; = 0.02). The +43AA genotype was associated with lower overall survival (OS) than the +43GG genotype. Our results suggest that the genotype plays a role in CRC risk. This is the first study to identify an association between five polymorphisms and CRC incidence worldwide.