A novel selective ternary platform fabricated with MgAl-layered double hydroxide/NiMnO functionalized polyaniline nanocomposite deposited on a glassy carbon electrode for electrochemical sensing of levodopa.

In this study, a novel selective electrochemical sensor was fabricated for determination of levodopa (LD) using a glassy carbon electrode modified with MgAl-layered double hydroxide/NiMnO functionalized polyaniline nanocomposite (LDH/NMO/PANI) and its successful formation was confirmed by various techniques. Owing to the high surface area and outstanding conductivity features provided by the combination of MgAl-LDH, NiMnO and PANI nanoparticles, this ternary nanocomposite exhibited excellent electrochemical activity towards the detection of LD compared with the electrode modified by the pristine MgAl-LDH and MgAl-LDH/NiMnO binary nanocomposite. In addition, enormous quantities of amine and imine functional groups on the surface of PANI lead to a strong affinity for attachment to organic molecules such as LD. The ternary nanocomposite modified electrode exhibited excellent analytical parameters such as wide linear response from 0.1 to 100 μM with very low detection limit of 0.005 μM, good reproducibility and long-term stability which are superior among the LD electrochemical sensors. Besides, the constructive sensor possessed acceptable selectivity for recognition of LD in the presence of a variety of potentially interfering species and can also effectively avoid the interference of dopamine (DA) and ascorbic acid (AA). Consequently, the LDH/NMO/PANI/GC electrode was effectively applied to detect LD in human plasma and urine samples with good recoveries, ranging from 98.0-100.1% and it shows potential usage in clinical researches.