AI Article Synopsis
- The updated mechanostat model emphasizes the importance of osteocytes in managing bone adaptation to mechanical stress.
- The four mechanoadaptive pathways include: 1) formation modeling and targeted remodeling (with increased loading), 2) resorption modeling, and 3) disuse-mediated remodeling (during inactivity).
- These pathways work together to adjust whole-bone stiffness based on varying mechanical demands placed on the bone.
Article Abstract
We review evidence supporting an updated mechanostat model in bone that highlights the central role of osteocytes within bone's four mechanoadaptive pathways: 1) formation modeling and 2) targeted remodeling, which occur with heightened mechanical loading, 3) resorption modeling, and 4) disuse-mediated remodeling, which occur with disuse. These four pathways regulate whole-bone stiffness in response to changing mechanical demands.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310270 | PMC |
| http://dx.doi.org/10.1249/JES.0000000000000225 | DOI Listing |
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