Antibacterial and NF-κB Inhibitory Lumazine Peptides, Aspochalasin, γ-Butyrolactone Derivatives, and Cyclic Peptides from a Hawaiian .

Five new lumazine peptides (-), a new aspochalasin derivative (), and a new γ-butyrolactone derivative (), together with seven known compounds (-), were isolated from a Hawaiian fungal strain, FS888. Compound is an uncommon natural product containing an isocyano group. The structures of the new compounds - were elucidated by NMR spectroscopy, HRESIMS, chemical derivatization, and ECD analysis. Compounds - showed significant antibacterial activity against when in combination with disulfiram. Additionally, compounds and showed NF-κB inhibitory activity with IC values of 3.1 ± 1.0 and 10.3 ± 2.0 μM, respectively.