Introduction: Chondrocalcinosis is a common joint condition in people over 50, characterized by the deposition of calcium pyrophosphate crystals that causes calcification in cartilage structures. Although its prevalence in the general population is 5%, sclerochoroidal calcifications are a rare finding in this pathology.
Objective: Describe the case of a 60-year-old man with choroidal calcification in the left eye, associated with radiological findings of chondrocalcinosis, whose metabolic report showed parameters compatible with hyperparathyroidism.
Clinical Case: Male patient from Mexico City, smoker for 45 years, with medical history of calcium pyrophosphate deposition disease at age 16, attended routine eye examination. A left eye funduscopy revealed an irregularly shaped white-yellowish subretinal lesion with well-defined edges inside the upper temporal arch. Ophthalmological paraclinical studies were performed, and a choroidal hyperreflectic paramacular plate image, which did not involve the retina layers, was corroborated with five-line optical coherence tomography.
Conclusions: Although the lesions are asymptomatic and do not require treatment, it is of great importance to make a differential diagnosis with choroidal metastases, choroidal melanoma, choroidal osteoma and lymphoma, since these pathologies do require more aggressive treatment.
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Skeletal Radiol
January 2025
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Yawkey 6044, Boston, MA, 02114, USA.
The radiological manifestations of calcium pyrophosphate deposition (CPPD) revolve around two main axes: the asymptomatic form and CPPD disease. The latter is a consequence of an immune response to calcium phosphate crystals. Chondrocalcinosis is broadly considered the radiographic manifestation of CPPD regardless of whether it is asymptomatic or associated with inflammatory arthritis.
View Article and Find Full Text PDFACS Biomater Sci Eng
January 2025
CIRIMAT, Toulouse INP, Université Toulouse 3 Paul Sabatier, CNRS, Université de Toulouse, ENSIACET, 4 allée Emile Monso, Toulouse 31030, France.
Pyrophosphate-stabilized amorphous calcium carbonates (PyACC) are promising compounds for bone repair due to their ability to release calcium, carbonate, and phosphate ions following pyrophosphate hydrolysis. However, shaping these metastable and brittle materials using conventional methods remains a challenge, especially in the form of macroporous scaffolds, yet essential to promote cell colonization. To overcome these limitations, this article describes for the first time the design and multiscale characterization of freeze-cast alginate (Alg)-PyACC nanocomposite scaffolds.
View Article and Find Full Text PDFAm J Med
December 2024
Department of Family Practice, Ehime Seikyo Hospital, Ehime, Japan.; Center for General Medicine Education, School of Medicine, Keio University, Tokyo, Japan.. Electronic address:
Int J Mol Sci
December 2024
Department of Medical and Surgical Sciences, "Magna Grecia" University, 88100 Catanzaro, Italy.
Vascular calcification (VC) is a biological phenomenon characterized by an accumulation of calcium and phosphate deposits within the walls of blood vessels causing the loss of elasticity of the arterial walls. VC plays a crucial role in the incidence and progression of chronic kidney disease (CKD), leading to a significant increase in cardiovascular mortality in these patients. Different conditions such as age, sex, dyslipidemia, diabetes, and hypertension are the main risk factors in patients affected by chronic kidney disease.
View Article and Find Full Text PDFRheumatology (Oxford)
December 2024
Academic Rheumatology, University of Nottingham, Nottingham, UK.
Objective: To develop and validate a patient-reported definition of acute calcium pyrophosphate (CPP) crystal arthritis in people with crystal-proven CPP deposition (CPPD) disease.
Methods: Consecutive patients with crystal-proven CPPD disease from seven centres across four countries were enrolled in a cross-sectional study. In each centre, patient-reported outcomes on the features of acute CPP crystal arthritis were collected.
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