AI Article Synopsis
- * A study analyzed HAdV-55 isolates from various countries between 1969 and 2018 using whole-genome sequencing and phylogenetic analyses, revealing a global presence and a high degree of genetic similarity among recent strains.
- * The research highlights that some strains have persisted regionally, while certain mutations may influence the virus's infectivity and transmission patterns.
Article Abstract
Human adenovirus type 55 (HAdV-55) causes acute respiratory disease of variable severity and has become an emergent threat in both civilian and military populations. HAdV-55 infection is endemic to China and South Korea, but data from other regions and time periods are needed for comprehensive assessment of HAdV-55 prevalence from a global perspective. In this study, we subjected HAdV-55 isolates from various countries collected during 1969-2018 to whole-genome sequencing, genomic and proteomic comparison, and phylogenetic analyses. The results show worldwide distribution of HAdV-55; recent strains share a high degree of genomic homogeneity. Distinct strains circulated regionally for several years, suggesting persistent local transmission. Several cases of sporadic introduction of certain strains to other countries were documented. Among the identified amino acid mutations distinguishing HAdV-55 strains, some have potential impact on essential viral functions and may affect infectivity and transmission.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323512 | PMC |
| http://dx.doi.org/10.3201/eid2607.191707 | DOI Listing |
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