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Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease.
J Inflamm Res
January 2025
Department of Infectious Disease, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.
Chronic liver disease ranks as the 11th leading cause of death worldwide, while hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality, representing a substantial risk to public health. Over the past few decades, the global landscape of chronic liver diseases, including hepatitis, metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis, and HCC, has undergone substantial changes. Copper, a vital trace element for human health, is predominantly regulated by the liver.
View Article and Find Full Text PDFPractical Steps to Design Brucellosis Preventive Interventions: An Intervention Mapping Approach.
Health Sci Rep
January 2025
Department of Public Health, School of Public Health Ardabil University of Medical Sciences Ardabil Iran.
Background And Aims: Common diseases between humans and animals are one of the health problems of countries, which requires targeted intervention. The intervention mapping model provides guidance for choosing the most appropriate methods and applications. Since one of the most important challenges in the endemic areas of Iran is the control of brucellosis.
View Article and Find Full Text PDFIdentifying targets for antibiotic stewardship interventions in pediatric patients in Punjab, Pakistan: point prevalence surveys using AWaRe guidance.
Front Pediatr
January 2025
Department of Public Health Pharmacy and Management, School of Pharmacy, Sefako Makgatho Health Sciences University, Ga-Rankuwa, South Africa.
Introduction: Surveillance of antibiotic use is crucial for identifying targets for antibiotic stewardship programs (ASPs), particularly in pediatric populations within countries like Pakistan, where antimicrobial resistance (AMR) is escalating. This point prevalence survey (PPS) seeks to assess the patterns of antibiotic use in pediatric patients across Punjab, Pakistan, employing the WHO AWaRe classification to pinpoint targets for intervention and encourage rational antibiotic usage.
Methods: A PPS was conducted across 23 pediatric wards of 14 hospitals in the Punjab Province of Pakistan using the standardized Global-PPS methodology developed by the University of Antwerp.
Population-Wide Vaccination Hesitancy among the Amish: A County-Level Study of COVID-19 Vaccine Adoption and Implications for Public Health Policy and Practice.
Popul Res Policy Rev
July 2023
Population Research Institute, Pennsylvania State University, University Park, PA.
Spatially concentrated, vaccine-hesitant populations represent an ongoing challenge to public health policies that emphasize mass vaccination as a means to eradicating certain infectious diseases. Previous research suggests that Amish populations, which are spatially clustered and rapidly growing, may be undervaccinated. However, existing evidence is limited to local case studies in pre-COVID-19 contexts.
View Article and Find Full Text PDFReducing off-target expression of mRNA therapeutics and vaccines in the liver with microRNA binding sites.
Mol Ther Methods Clin Dev
March 2025
Department of Medicine, Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55902, USA.
Lipid nanoparticles (LNPs) are often liver tropic, presenting challenges for LNP-delivered mRNA therapeutics intended for other tissues, as off-target expression in the liver may increase side effects and modulate immune responses. To avoid off-target expression in the liver, miR-122 binding sites have been used by others in viral and non-viral therapeutics. Here, we use a luciferase reporter system to compare different copy numbers and insertion locations of miR-122 binding sequences to restrict liver expression.
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