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GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy.
Mol Ther
January 2025
Shanghai Frontiers Science Center of Genome Editing and Cell Therapy, Shanghai Key Laboratory of Regulatory Biology and School of Life Sciences, East China Normal University, Shanghai, China, 200241. Electronic address:
CAR T-cell therapy has achieved remarkable clinical success in treating hematological malignancies. However, its clinical efficacy in solid tumors is less satisfactory, partially due to poor in vivo expansion and limited persistence of CAR-T cells. Here, we demonstrated that the overexpression of glucocorticoid-induced tumor necrosis factor receptor-related protein ligand (GITRL) enhances the anti-tumor activity of CAR-T cells.
View Article and Find Full Text PDFSubclinical depressive symptoms and job stress differentially impact memory in working and retired older adults.
Sci Rep
January 2025
Department of Psychological Sciences, Rice University, 6100 Main St, Houston, TX, 77005, USA.
Retirement has been associated with cognitive decline beyond normal age-related decline. However, there are many individual differences in retirement that can influence cognition. Subclinical depressive symptoms are common in late life and are associated with general memory decline and a bias towards remembering negative events (i.
View Article and Find Full Text PDFGRAiCE: reconstructing terrestrial water storage anomalies with recurrent neural networks.
Sci Data
January 2025
Department of Earth and Environmental Engineering, Columbia University, New York, USA.
The Gravity Recovery and Climate Experiment (GRACE) and its follow-on (GRACE-FO) missions have provided estimates of Terrestrial Water Storage Anomalies (TWSA) since 2002, enabling the monitoring of global hydrological changes. However, temporal gaps within these datasets and the lack of TWSA observations prior to 2002 limit our understanding of long-term freshwater variability. In this study, we develop GRAiCE, a set of four global monthly TWSA reconstructions from 1984 to 2021 at 0.
View Article and Find Full Text PDFPhysical unclonable in-memory computing for simultaneous protecting private data and deep learning models.
Nat Commun
January 2025
Beijing Advanced Innovation Center for Integrated Circuits, School of Integrated Circuits, Peking University, Beijing, China.
Compute-in-memory based on resistive random-access memory has emerged as a promising technology for accelerating neural networks on edge devices. It can reduce frequent data transfers and improve energy efficiency. However, the nonvolatile nature of resistive memory raises concerns that stored weights can be easily extracted during computation.
View Article and Find Full Text PDFThe neural basis of the insight memory advantage.
Trends Cogn Sci
January 2025
Department of Psychology, Humboldt University Berlin, Berlin, Germany; Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA.
Creative problem solving and memory are inherently intertwined: memory accesses existing knowledge while creativity enhances it. Recent studies show that insights often accompanying creative solutions enhance long-term memory. This insight memory advantage (IMA) is explained by the 'insight as prediction error (PE)' hypothesis which states that insights arise from PEs updating predictive solution models and thereby enhancing memory.
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