Nivolumab-Induced Bullous Pemphigoid Managed without Drug Withdrawal.

Indian J Dermatol

Department of Dermatology, Germans Trias I Pujol University Hospital, Universitat Autònoma De Barcelona, Badalona, Spain.

Published: January 2020

The widespread use of anti-programmed cell death receptor-1 (PD-1) agents has shed light to unusual immune-related adverse effects, especially affecting the skin. We report a case of bullous pemphigoid secondary to nivolumab therapy for metastatic renal carcinoma with a previously unreported complete response to clobetasol ointment alone. The autoimmune blistering disease was successfully treated without oral corticosteroids, and the anti-PD-1 agent could be maintained without recurrence of the skin lesions. Topical therapy remains a good option in selected, mild-to-moderate cases of induced bullous pemphigoid.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292470PMC
http://dx.doi.org/10.4103/ijd.IJD_321_18DOI Listing

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