AI Article Synopsis
- - The study investigates the relationship between Duffy blood group phenotypes and T. gondii infection in 576 patients, exploring whether Duffy antigens influence the invasion of the parasite.
- - Results indicate that T. gondii infection was more common in patients with the disease (22.9% presence) and those with positive anti-T. gondii IgG antibodies compared to those without the infection; however, no significant association was found with Duffy phenotypes.
- - Ultimately, the findings suggest that Duffy blood group phenotypes and their antigens do not increase the risk for T. gondii infection or the associated disease (OT).
Article Abstract
Duffy blood group phenotypes [Fy(a + b-), Fy(a-b+), Fy(a + b+), Fy(a-b-)], characterized by the expression of Fy, and Fy antigens, are present in red blood cells. Therefore, we hypothesize that the non-hematopoietic expression of these antigens might influence cell invasion by T. gondii. 576 consecutive patients from both genders were enrolled. The presumed OT clinical diagnosis was performed. Duffy phenotyping was performed by hemagglutination in gel columns and for the correct molecular characterization Fy(a-b-) phenotype, using PCR-RFLP. Anti-T. gondii IgG antibodies were detected by ELISA. Chi-square, Fisher's exact tests were used to compare the proportions. OT was present in 22.9% (n = 132) and absent in 77.1% (n = 444) of patients. The frequencies of anti-T. gondii IgG antibodies were higher in OT (127/132, 96.2%) than those without this disease (321/444, 72.3%) (p < .0001). None of the Duffy antigens or phenotypes were associated with T. gondii infection (χ2: 2.222, GL: 3, p = .5276) as well as the risk of OT (χ2: 0.771, GL: 3, p = .8566). Duffy blood group system phenotypes and their antigens do not constitute risk factors for infection by T. gondii infection and the development of OT.
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| http://dx.doi.org/10.1016/j.meegid.2020.104430 | DOI Listing |
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