Quality is the lifeline for all pharmaceuticals. Process analytical technology (PAT), introduced by FDA in 2004, providing significant opportunities for improving pharmaceutical development, manufacturing, and quality assurance. Therefore, in this review various PAT tools were introduced for solid oral dosage manufacture quality monitor and control. Throughout this review, we would like to provide more information to both researchers and manufacturers in order to improve the drug quality.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejpb.2020.06.008 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Systematic review and meta-analysis of the treatment of hypernatremia in adult hospitalized patients: impact on mortality, morbidity, and treatment-related side effects.
J Crit Care
January 2025
Department of Critical Care, School of Medicine, University of Melbourne, Parkville, Victoria, Australia; Department of Intensive Care, Royal Melbourne Hospital, Parkville, Victoria, Australia; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia; Data Analytics Research and Evaluation, Austin Hospital, Melbourne, Australia. Electronic address:
Background: Hypernatremia is relatively common in acutely ill patients and associated with mortality. Guidelines recommend a slow rate of correction (≤ 0.5 mmol/L per hour).
View Article and Find Full Text PDFQuantitative association of SARS-CoV-2 in wastewater and clinically confirmed cases in different areas of the Tokyo 2020 Olympic and Paralympic Village.
Sci Total Environ
January 2025
Human Genome Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
International mass gathering events, such as the Olympic and Paralympic Games, face the risk of cross-border transmission of infectious diseases. We previously reported that wastewater-based epidemiology (WBE), which has attracted attention as a COVID-19 surveillance tool, was implemented in the Tokyo 2020 Olympic and Paralympic Village to gain a comprehensive understanding of COVID-19 incidence in the village. In the present study, we explored the quantitative association of wastewater viral load and clinically confirmed cases in various areas of the village.
View Article and Find Full Text PDFUnveiling per- and polyfluoroalkyl substances contamination in e-cigarette refill liquids: A comprehensive analytical assessment.
Sci Total Environ
January 2025
Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology (GUT), ul. G. Narutowicza 11/12, 80-233 Gdańsk, Poland; EcoTech Center, Gdańsk University of Technology (GUT), ul. G. Narutowicza 11/12, 80-233 Gdańsk, Poland.
A robust analytical method was developed for the determination of per- and polyfluoroalkyl substances (PFAS) in e-cigarette refill liquids using solid-phase extraction (SPE) with weak anion-exchange sorbent, followed by detection with high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The design of experiment approach was employed to optimize sample preparation, leading to the validation of the method with limits of detection for PFAS ranging from 0.24 to 1.
View Article and Find Full Text PDFComprehensive determination of elements ranging from uranium to americium by hybrid measurement of fluorescent and spontaneously emitted characteristic X-rays.
Talanta
January 2025
National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Chiba, Chiba, 263-8555, Japan; Department of Physics, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.
Natural uranium isotopes have extremely long half-lives; therefore, analytical methods based on the number of atoms, such as X-ray fluorescence (XRF) analysis, are suitable for uranium detection. However, XRF measurements cannot be used to detect the major isotopes of americium when present in amounts barely detectable using radiation measurements, owing to their relatively short half-lives. Because of α-decay-induced internal conversion, where orbital electrons are emitted instead of γ-rays, these nuclides emit characteristic X-rays.
View Article and Find Full Text PDF1,4-Dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxylic acid as a novel MALDI matrix for enhanced analysis of metabolites induced by imidacloprid exposure.
Talanta
January 2025
Ministry of Education Key Laboratory of Analytical Science for Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350108, China. Electronic address:
Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a robust tool for analyzing a variety of biomacromolecules. However, the strong background interference produced by conventional organic matrices hinders the detection of small molecule analytes, which restricts the widespread application of MALDI-MS in metabolomics studies. Consequently, developing new organic matrices is urgently needed to overcome these issues.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!