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The H-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.
Am J Physiol Cell Physiol
March 2021
Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
A primary function of the H-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes. Its activity allows for the acidification of intracellular vesicles and organelles, which is necessary for many essential cell biological events to occur. In addition, many specialized cell types in various organ systems such as the kidney, bone, male reproductive tract, inner ear, olfactory mucosa, and more, use plasma membrane V-ATPases to perform specific activities that depend on extracellular acidification.
View Article and Find Full Text PDFA new player in the kidney-bone axis: regulation of fibroblast growth factor-23 by renal glycerol-3-phosphate.
Kidney Int
November 2020
Inserm Unit 1018, Team 5, Centre de recherche en Epidémiologie et Santé des Populations (CESP), Hôpital Paul Brousse, Paris-Sud University (UPS), Villejuif, France; Versailles Saint-Quentin-en-Yvelines University (Paris-Ile-de-France-Ouest University, UVSQ), Villejuif, France. Electronic address:
The discovery of alpha-Klotho and FGF23 unveiled new insight into calcium and phosphate homeostasis.
Cell Mol Life Sci
October 2008
Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Yoshida Konoe-cho Sakyu-ku, Kyoto, 606 - 8501, Japan.
1The traditional view of calcium homeostasis is that it is maintained by two essential reactions. First, changes in extracellular Ca2+ are sensed in several distinct cell types, stimulating the secretion of parathyroid hormone (PTH), 1,25(OH)(2) D and calcitonin in response to the body's requirement. Second, these calcitropic hormones then act on the calcium-translocating cells of the kidney, bone, and intestine to restore calcium balance.
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