Osteoarthritis (OA) is a long-term and inflammatory disorder featured by cartilage erosion. Here, we describe nomilin (NOM), a triterpenoid with inflammation modulatory properties in variety of disorders. In this study, we demonstrated the latent mechanism of NOM in alleviating the progress of OA both in vitro and in vivo studies. The results showed that NOM pre-treatment suppressed the IL-1β-induced over-regulation of pro-inflammation factors, such as NO, IL-6, PGE , iNOS, TNF-α and COX-2. Moreover, NOM also down-regulates the degradation of ECM induced by IL-1β. Mechanistically, the NOM suppressed NF-κB signalling via disassociation of Keap1-Nrf2 in chondrocytes. Furthermore, NOM delays the disease progression in the mouse OA model. To sum up, this research indicated NOM possessed a new potential therapeutic option in osteoarthritis.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412705PMC
http://dx.doi.org/10.1111/jcmm.15484DOI Listing

Publication Analysis

Top Keywords

nom
7
nomilin targets
4
targets keap1-nrf2
4
keap1-nrf2 signalling
4
signalling ameliorates
4
ameliorates development
4
development osteoarthritis
4
osteoarthritis osteoarthritis
4
osteoarthritis long-term
4
long-term inflammatory
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!