Prevention of perinatal complications in pregnant women with chronic papillomavirus infection.

Unlabelled: Social trends, a new style of modern young woman, which includes the polygamy of sexual relationships, increases the incidence and probability of infection caused by sexually transmitted pathogens, including the human papillomavirus. In women entered into motherhood with chronic papillomavirus carrier, pregnancy is accompanied with an increase in obstetrics and perinatal complications. The inability to use antiviral therapy due to its embryo- and fetotoxic effects requires searching for safe agents for timely and effective preconceptional and prenatal preparation for the fetal infection prevention.

Aim: The aim of the study was to evaluate a reduce level of obstetrics and perinatal complications in pregnant women infected with the human papillomavirus by using adequate preconceptional and prenatal preparation.

Materials And Methods: The immune status assessment was provided in 89 women who were chronic carriers of papillomavirus infection by determining the T and B lymphocyte levels, the concentration of proinflammatory (IL-2, IL-6, TNF-α) and anti-inflammatory (IL-4, IL-10) factors and the follow-up analysis of the pregnancy course and childbirth.

Results: Pregnancy course in women who are chronic carriers of human papillomavirus infection is accompanied by the high incidence of perinatal complications such as placental dysfunction, polyhydramnios, gestosis, premature membrane rupture, preterm labour, oligohydramnios, and fetal growth retardation syndrome. Chronic carriage of human papillomavirus infection leads to decrease in the CD3+, CD4+, and CD19+ levels associated with an increased CD8+ level and activation of proinflammatory cytokines (IL-2, IL-6, TNF-α) against the background of a decrease in their anti-inflammatory concentration analogues (IL-4, IL- 10) during pregnancy, which, in turn, creates favourable conditions for viral reactivation and subsequently causes reproductive complications and losses.

Conclusions: The use of Proteflazid which contain a complex of plant flavonoids with a direct antiviral effect on human papillomavirus, for the purpose of preconceptional and prenatal preparation in women who are chronic carriers of human papillomavirus infection, contributes to the pregnant woman's immune balance restoration and significant perinatal complication reduction.