Naturally acquired anti-Plasmodium falciparum immunity protects first and foremost against severe disease. Raj et al. have established a tantalizing path towards an anti-disease vaccine by identifying glutamic acid-rich protein (GARP) antibodies as signatures of protection against severe malaria in Tanzanian children and demonstrating efficacy in blood cultures and monkey trials.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pt.2020.05.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Circulating T-follicular helper (cT ) cells have the potential to provide an additional correlate of protection against ( as they are essential to promote B cell production of long-lasting antibodies. Assessing the specificity of cT subsets to individual malaria antigens is vital to understanding the variation observed in antibody responses and identifying promising malaria vaccine candidates.
Methods: Using spectral flow cytometry and unbiased clustering analysis we assessed antigen-specific cT cell recall responses to malaria vaccine candidates SEA-1A and GARP within a cross-section of children and adults living in a malaria holoendemic region of western Kenya.
Single cell transcriptional changes across the blood stages of artemisinin resistant K13 upon dihydroartemisinin exposure.
bioRxiv
September 2024
Department of Pathology and Laboratory Medicine, Brown University, Providence, RI.
Artemisinins have been a cornerstone of malaria control, but resistance in , due to mutations in the Kelch13 (K13) protein, threaten these advances. Artemisinin exposure results in a dynamic transcriptional response across multiple pathways, but most work has focused on ring stages and transcriptional analysis. We applied single cell RNAseq to two unsynchronized coisogenic parasite lines (K13 and K13) over 6 hrs after a pulse exposure to dihydroartemisinin (DHA).
View Article and Find Full Text PDFMalaria According to GARP: A New Trail towards Anti-disease Vaccination.
Trends Parasitol
August 2020
Department of Molecular Parasitology, Institute of Biology, Humboldt University, 10115 Berlin, Germany.
Naturally acquired anti-Plasmodium falciparum immunity protects first and foremost against severe disease. Raj et al. have established a tantalizing path towards an anti-disease vaccine by identifying glutamic acid-rich protein (GARP) antibodies as signatures of protection against severe malaria in Tanzanian children and demonstrating efficacy in blood cultures and monkey trials.
View Article and Find Full Text PDFAnti-PfGARP activates programmed cell death of parasites and reduces severe malaria.
Nature
June 2020
Center for International Health Research, Rhode Island Hospital, Brown University Medical School, Providence, RI, USA.
Malaria caused by Plasmodium falciparum remains the leading single-agent cause of mortality in children, yet the promise of an effective vaccine has not been fulfilled. Here, using our previously described differential screening method to analyse the proteome of blood-stage P. falciparum parasites, we identify P.
View Article and Find Full Text PDFHuman erythrocyte band 3 is a host receptor for glutamic acid-rich protein.
Blood
January 2019
Graduate Program in Pharmacology and Experimental Therapeutics and.
Article Synopsis
- * Researchers identified a protein called PfGARP from malaria parasites that binds to a receptor on human red blood cells, which may enhance the red blood cells' adhesive properties and contribute to severe disease symptoms like rosetting.
- * The study developed a qualitative assay to detect immune responses against PfGARP in patients, suggesting it could serve as a biomarker for malaria progression and offers potential for new treatments by targeting PfGARP to reduce malaria-related complications.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!