TLR2 as a Therapeutic Target in Bacterial Infection.

Trends Mol Med

Department of Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA, USA; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA. Electronic address:

Published: August 2020

Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections and can influence the downstream immune response to the host's benefit or detriment. Therapeutic modulation of TLR2 signaling represents an underutilized opportunity to moderate the immune response to infection to promote an improved outcome for the host.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845793PMC
http://dx.doi.org/10.1016/j.molmed.2020.05.006DOI Listing

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