Unlabelled: Amnestic Mild Cognitive Impairment (aMCI) is now recognized as an early risk state for the development of Alzheimer's dementia (AD). Biomarkers, including those that are cerebrospinal fluid or brain imaging based, have yet to provide the ultimate marker variable. A need currently exists for a non-invasive, easy to administer biomarker that contains aMCI/AD specific pathognomic information.
Objective: The objective of the present investigation was to provide an updated review of the Flash Visual Evoked Potential-P2 (FVEP-P2) as a biomarker for aMCI and AD. The FVEP-P2 has been shown to possess AD specific pathognomic information.
Method: A review was conducted of all articles published between the years 1976 and 2019 that examined the clinical utility of the FVEP-P2 in the diagnosis of aMCI or AD. Only 17 published investigations met the criteria of the review.
Result: The weighted average effect size, as measured by Cohen's d, was 1.07, with patients diagnosed with either aMCI or AD exhibiting a significant delay in the FVEP-P2 latency. The weighted mean latency for the controls was 143.92 ms (SD = 17.13). The weighted mean latency for the aMCI/AD was 164.02 ms (SD = 21.33). Estimates of sensitivity, specificity, and accuracy were based on the weighted means and standard deviations and were equal to 0.73. The area under the curve was equal to 0.78.
Conclusion: The results of the current review suggest that the FVEP-P2 latency possesses AD specific pathognomic information and that it should be included as part of a much larger assessment process that includes neuropsychological, cerebrospinal fluid, and brain imaging findings.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijpsycho.2020.05.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Objective: Aim: To make a systematic review and meta-analysis of published data on the study of histological and immunohistochemical features of the placenta in women who had acute coronavirus infection associated with SARS-CoV-2 ("Covid" placentas) during pregnancy.
Patients And Methods: Materials and Methods: The search for literature data is based on the PRISMA methodology); the MEDLINE database (PubMed®) was searched using Medical Subject Headings terms from January 2020 to July 2023. The project was registered in the Open Sience Frame (Project Identifier: DOI 10.
Development and validation of novel keloid-derived immortalized fibroblast cell lines.
Front Immunol
June 2024
MRC Wound Healing and Keloid Research Unit, Hair and Skin Research Laboratory, Division of Dermatology, Department of Medicine, Faculty of Health Sciences, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.
Article Synopsis
- Keloids are a type of connective tissue disorder that currently lack effective treatment and have no suitable animal models for study.
- Researchers have created keloid-derived immortalized fibroblast (KDIF) cell lines from primary keloid fibroblasts by introducing the human telomerase reverse transcriptase gene, which helps cells replicate indefinitely.
- The KDIF cell lines demonstrate unique growth characteristics and faster proliferation compared to normal fibroblasts, indicating their potential as a reliable model for studying keloid pathology.
The GLP-1 receptor is expressed by human metastatic prostate cancer.
Endocr Oncol
January 2024
Molecular Imaging and Therapeutic Nuclear Medicine, Cancer Imaging, Prostate Cancer Theranostics and Imaging Centre of Excellence (ProsTIC), Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Objectives: The glucagon-like peptide-1 (GLP-1) receptor agonist, liraglutide, reduces human prostate cancer incidence, and similar GLP-1 receptor agonists reduce proliferation and growth of prostate cancer cell lines. Primary human prostate cancer expresses the GLP-1 receptor (GLP-1R) . Cancer evolves with stage, and whether advanced-stage human prostate cancer expresses GLP-1R is unknown.
View Article and Find Full Text PDFComparison of Follicular Helper T-Cell Markers with the Expression of the Follicular Homing Marker CXCR5 in Peripheral T-Cell Lymphomas-A Reappraisal of Follicular Helper T-Cell Lymphomas.
Int J Mol Sci
December 2023
Laboratory of Tumor Pathology and Molecular Diagnostics, 6726 Szeged, Hungary.
Peripheral T-cell lymphomas (PTCLs) expressing multiple follicular T helper (TFH) cell-related antigens are now classified as TFH lymphomas (TFHL), including angioimmunoblastic, follicular, and not otherwise specified (NOS) types. CXCR5 is the TFH cell-defining chemokine receptor that, together with its ligand CXCL13, plays a critical role in the development of follicles and the positioning of TFH and B cells within follicles. A comprehensive immunomorphologic study was performed to investigate the expression pattern of CXCR5 in a large cohort of nodal PTCLs, particularly those with a TFH cell phenotype, and to compare its expression with six other TFH cell-related antigens.
View Article and Find Full Text PDF3. Pain originating from the lumbar facet joints.
Pain Pract
January 2024
Anesthesiology, Critical Care and Multidisciplinary Pain Center, Ziekenhuis Oost-Limburg, Genk, Belgium.
Introduction: Pain originating from the lumbar facets can be defined as pain that arises from the innervated structures comprising the joint: the subchondral bone, synovium, synovial folds, and joint capsule. Reported prevalence rates range from 4.8% to over 50% among patients with mechanical low back pain, with diagnosis heavily dependent on the criteria employed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!