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| http://dx.doi.org/10.1111/bph.15167 | DOI Listing |
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Nanopore sequencing as a novel method of characterising anorexia nervosa risk loci.
BMC Genomics
December 2024
Pathology and Biomedical Science Department, University of Otago Christchurch, Christchurch, New Zealand.
Background: Anorexia nervosa (AN) is a polygenic, severe metabopsychiatric disorder with poorly understood aetiology. Eight significant loci have been identified by genome-wide association studies (GWAS) and single nucleotide polymorphism (SNP)-based heritability was estimated to be ~ 11-17, yet causal variants remain elusive. It is therefore important to define the full spectrum of genetic variants in the wider regions surrounding these significantly associated loci.
View Article and Find Full Text PDFModeling bladder mechanics with 4D reconstruction of murine ex vivo bladder filling.
Biomech Model Mechanobiol
December 2024
Department of Mechanical Engineering, Michigan State University, East Lansing, MI, USA.
This study presents a novel methodology for high-resolution 3D bladder modeling during filling, developed by leveraging improved imaging and computational techniques. Using murine bladder filling data, the methodology generates accurate 3D geometries across time, enabling in-depth mechanical analysis. Comparison with a traditional spherical model revealed similar stress trends, but the 3D model permitted nuanced quantifications, such as localized surface curvature and stress analysis.
View Article and Find Full Text PDFDisruption of the β-catenin destruction complex via Ephexin1-Axin1 interaction promotes colorectal cancer proliferation.
Exp Mol Med
January 2025
Laboratory of Genomic Instability and Cancer Therapeutics, Gwangju, South Korea.
Wnt signaling is essential for cell growth and tumor formation and is abnormally activated in colorectal cancer (CRC), contributing to tumor progression; however, the specific role and regulatory mechanisms involved in tumor development remain unclear. Here, we show that Ephexin1, a guanine nucleotide exchange factor, is significantly overexpressed in CRC and is correlated with increased Wnt/β-catenin pathway activity. Through comprehensive analysis, including RNA sequencing data from TCGA and functional assays, we observed that Ephexin1 promotes tumor proliferation and migration by activating the Wnt/β-catenin pathway.
View Article and Find Full Text PDFMachine learning-based novel-shaped THz MIMO antenna with a slotted ground plane for future 6G applications.
Sci Rep
December 2024
EIAS Data Science Lab, College of Computer and Information Sciences, Prince Sultan University, Riyadh, 11586, Saudi Arabia.
This study discusses the results of using a regression machine learning technique to improve the performance of 6G applications that use multiple-input multiple-output (MIMO) antennas operating at the terahertz (THz) frequency band. This research evaluates an antenna's performance using various methodologies, such as simulation and RLC equivalent circuit models. The suggested design has a broad bandwidth of 2.
View Article and Find Full Text PDFOpen problems in synthetic multicellularity.
NPJ Syst Biol Appl
December 2024
Allen Discovery Center, Tufts University, Medford, MA, USA.
Multicellularity is one of the major evolutionary transitions, and its rise provided the ingredients for the emergence of a biosphere inhabited by complex organisms. Over the last decades, the potential for bioengineering multicellular systems has been instrumental in interrogating nature and exploring novel paths to regeneration, disease, cognition, and behaviour. Here, we provide a list of open problems that encapsulate many of the ongoing and future challenges in the field and suggest conceptual approaches that may facilitate progress.
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