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Quantifying the topographical structure of rocky and coral seabeds.
PLoS One
June 2024
GEOSCIENCES-Montpellier, Univ Montpellier, CNRS, Montpellier, France.
Describing the structural complexity of seabeds is of primary importance for a number of geomorphological, hydrodynamical and ecological issues. Aiming to bring a decisive insight on the long-term development of a unified view, the present study reports on a comparative multi-site analysis of high resolution topography surveys in rough nearshore environments. The nine study sites have been selected to cover a wide variety of topographical features, including rocky and coral seabeds.
View Article and Find Full Text PDFAtypical connectome topography and signal flow in temporal lobe epilepsy.
Prog Neurobiol
May 2024
Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC H3A 2B4, Canada. Electronic address:
Temporal lobe epilepsy (TLE) is the most common pharmaco-resistant epilepsy in adults. While primarily associated with mesiotemporal pathology, recent evidence suggests that brain alterations in TLE extend beyond the paralimbic epicenter and impact macroscale function and cognitive functions, particularly memory. Using connectome-wide manifold learning and generative models of effective connectivity, we examined functional topography and directional signal flow patterns between large-scale neural circuits in TLE at rest.
View Article and Find Full Text PDFMulti-site lumbar transcutaneous spinal cord stimulation: When less is more.
Neurosci Lett
January 2024
Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, USA. Electronic address:
Background: Transcutaneous spinal stimulation (TSS) has become a valuable tool for facilitating rehabilitation in individuals with neurological deficits. A significant constraint arises from the need for precise knowledge of stimulation locations to effectively apply TSS for targeted functional enhancement.
Methods: In this study, we investigate whether single-site or simultaneous multi-site stimulation over the lumbar spinal cord is advantageous for recruitment of specific motor pools projecting to lower limb muscles and generates higher leg extensor forces in neurologically intact individuals.
Atypical connectome topography and signal flow in temporal lobe epilepsy.
bioRxiv
May 2023
Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Temporal lobe epilepsy (TLE) is one of the most common pharmaco-resistant epilepsies in adults. While hippocampal pathology is the hallmark of this condition, emerging evidence indicates that brain alterations extend beyond the mesiotemporal epicenter and affect macroscale brain function and cognition. We studied macroscale functional reorganization in TLE, explored structural substrates, and examined cognitive associations.
View Article and Find Full Text PDFTopographic divergence of atypical cortical asymmetry and atrophy patterns in temporal lobe epilepsy.
Brain
May 2022
Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
Article Synopsis
- Temporal lobe epilepsy (TLE) is mainly a limbic network disorder characterized by unilateral hippocampal issues and has been studied using structural MRI for brain grey matter changes.
- The study utilized the ENIGMA-Epilepsy dataset to compare grey matter asymmetry and atrophy in TLE patients versus healthy controls, finding distinct patterns: atypical asymmetry showed a temporo-limbic signature, while atrophy appeared diffuse and bilateral.
- Results indicated that cortical atrophy correlates with factors like disease duration and age at seizure onset, while asymmetry levels did not, suggesting that these two measures capture different but complementary aspects of TLE pathology.
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