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Interaction Between NOS3 and HMOX1 on Antihypertensive Drug Responsiveness in Preeclampsia. | LitMetric
Objective : We examined the interaction of polymorphisms in the genes heme oxygenase-1 () and nitric oxide synthase () in patients with preeclampsia (PE) as well as the responsiveness to methyldopa and to total antihypertensive therapy.Methods : The genes (rs2071746, A/T) and (rs1799983, G/T) were genotyped using TaqMan allele discrimination assays (Applied Biosystems, Foster City, CA, USA ), and the levels of enzyme heme oxygenase-1 HO-1) were measured using enzyme-linked immunosorbent assay (ELISA).Results : We found interactions between genotypes of the and genes and responsiveness to methyldopa and that PE genotyped as AT presents lower levels of protein HO-1 compared with AA.Conclusion : We found interactions between the and genes and responsiveness to methyldopa and that the polymorphism affects the levels of enzyme HO-1 in responsiveness to methyldopa and to total antihypertensive therapy. These data suggest impact of the combination of these two polymorphisms on antihypertensive responsiveness in PE.
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